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1

NK and NKT Cells in Aging and Longevity: Role of Zinc and Metallothioneins

Eugenio Mocchegiani, Robertina Giacconi, Catia Cipriano, Marco Malavolta

Journal:

Journal of Clinical Immunology

Year:

2009

Language:

english

File:

PDF, 220 KB

english, 2009

2

Nutrient–gene interaction in ageing and successful ageing: A single nutrient (zinc) and some target genes related to inflammatory/immune response

Eugenio Mocchegiani, Laura Costarelli, Robertina Giacconi, Catia Cipriano, Elisa Muti, Silvia Tesei, Marco Malavolta

Journal:

Mechanisms of Ageing and Development

Year:

2006

Language:

english

File:

PDF, 255 KB

english, 2006

3

Plasticity of neuroendocrine–thymus interactions during ontogeny and ageing: Role of zinc and arginine

Eugenio Mocchegiani, Lory Santarelli, Laura Costarelli, Catia Cipriano, Elisa Muti, Robertina Giacconi, Marco Malavolta

Journal:

Ageing Research Reviews

Year:

2006

Language:

english

File:

PDF, 583 KB

english, 2006

4

Distinctive modulation of inflammatory and metabolic parameters in relation to zinc nutritional status in adult overweight/obese subjects

Laura Costarelli, Elisa Muti, Marco Malavolta, Catia Cipriano, Robertina Giacconi, Silvia Tesei, Francesco Piacenza, Sara Pierpaoli, Nazzarena Gasparini, Emanuela Faloia, Giacomo Tirabassi, Marco Bosc

Journal:

The Journal of Nutritional Biochemistry

Year:

2010

Language:

english

File:

PDF, 196 KB

english, 2010

5

Interrelationship Among Neutrophil Efficiency, Inflammation, Antioxidant Activity and Zinc Pool in Very Old Age

Fausto Moroni, Maria Luisa Di Paolo, Adelio Rigo, Catia Cipriano, Robertina Giacconi, Rina Recchioni, Fiorella Marcheselli, Marco Malavolta, Eugenio Mocchegiani

Journal:

Year:

2005

Language:

english

File:

PDF, 273 KB

english, 2005

6

Inflammation, genes and zinc in ageing and age-related diseases

Sonya Vasto, Eugenio Mocchegiani, Giuseppina Candore, Florinda Listì, Giuseppina Colonna-Romano, Domenico Lio, Marco Malavolta, Robertina Giacconi, Catia Cipriano, Calogero Caruso

Journal:

Year:

2006

Language:

english

File:

PDF, 177 KB

english, 2006

7

Zinc, Immune Plasticity, Aging, and Successful Aging: Role of Metallothionein

EUGENIO MOCCHEGIANI, ROBERTINA GIACCONI, ELISA MUTI, CINZIA ROGO, MASSIMO BRACCI, MARIO MUZZIOLI, CATIA CIPRIANO, MARCO MALAVOLTA

Journal:

Annals of the New York Academy of Sciences

Year:

2004

File:

PDF, 1.62 MB

2004

8

Zinc, infections and immunosenescence

Eugenio Mocchegiani, Robertina Giacconi, Mario Muzzioli, Catia Cipriano

Journal:

Mechanisms of Ageing and Development

Year:

2001

Language:

english

File:

PDF, 111 KB

english, 2001

9

Metallothioneins/PARP-1/IL-6 interplay on natural killer cell activity in elderly: parallelism with nonagenarians and old infected humans. Effect of zinc supply

Eugenio Mocchegiani, Mario Muzzioli, Robertina Giacconi, Catia Cipriano, Nazzarena Gasparini, Claudio Franceschi, Remo Gaetti, Elisabetta Cavalieri, Hisanori Suzuki

Journal:

Mechanisms of Ageing and Development

Year:

2003

Language:

english

File:

PDF, 306 KB

english, 2003

10

In Vivo Effect of α-Bisabolol, a Nontoxic Sesquiterpene Alcohol, on the Induction of Spontaneous Mammary Tumors in HER-2/neu Transgenic Mice

Costarelli, Laura, Malavolta, Marco, Giacconi, Robertina, Cipriano, Catia, Gasparini, Nazzarena, Tesei, Silvia, Pierpaoli, Sara, Orlando, Fiorenza, Suzuki, Hisanori, Perbellini, Luigi, Piacenza, Franc

Journal:

Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics

Year:

2009

Language:

english

File:

PDF, 95 KB

english, 2009

11

Single and three-color flow cytometry assay for intracellular zinc ion availability in human lymphocytes with Zinpyr-1 and double immunofluorescence: Relationship with metallothioneins

Marco Malavolta, Laura Costarelli, Robertina Giacconi, Elisa Muti, Gianni Bernardini, Silvia Tesei, Catia Cipriano, Eugenio Mocchegiani

Journal:

Cytometry Part A

Year:

2006

Language:

english

File:

PDF, 759 KB

english, 2006

12

Are zinc-bound metallothionein isoforms (I+II and III) involved in impaired thymulin production and thymic involution during ageing?

Eugenio Mocchegiani, Robertina Giacconi, Catia Cipriano, Elisa Muti, Nazzarena Gasparini, Marco Malavolta

Journal:

Immunity & Ageing

Year:

2004

Language:

english

File:

PDF, 233 KB

english, 2004

13

Zinc-bound metallothioneins and immune plasticity: lessons from very old mice and humans

Eugenio Mocchegiani, Robertina Giacconi, Elisa Muti, Catia Cipriano, Laura Costarelli, Silvia Tesei, Nazzarena Gasparini, Marco Malavolta

Journal:

Immunity & Ageing

Year:

2007

Language:

english

File:

PDF, 255 KB

english, 2007

14

Novel -209A/G MT2A Polymorphism in Old Patients with Type 2 Diabetes and Atherosclerosis: Relationship with Inflammation (IL-6) and Zinc

Robertina Giacconi, Catia Cipriano, Elisa Muti, Laura Costarelli, Cardelli Maurizio, Vittorio Saba, Nazzarena Gasparini, Marco Malavolta, Eugenio Mocchegiani

Journal:

Year:

2005

Language:

english

File:

PDF, 176 KB

english, 2005

15

Involvement of −308 TNF-α and 1267 Hsp70-2 polymorphisms and zinc status in the susceptibility of coronary artery disease (CAD) in old patients

Robertina Giacconi, Catia Cipriano, Elisa Muti, Laura Costarelli, Marco Malavolta, Calogero Caruso, Domenico Lio, Eugenio Mocchegiani

Journal:

Year:

2006

Language:

english

File:

PDF, 211 KB

english, 2006

16

Polymorphisms in MT1a gene coding region are associated with longevity in Italian Central female population

Catia Cipriano, Marco Malavolta, Laura Costarelli, Robertina Giacconi, Elisa Muti, Nazzarena Gasparini, Maurizio Cardelli, Daniela Monti, Erminia Mariani, Eugenio Mocchegiani

Journal:

Year:

2006

Language:

english

File:

PDF, 180 KB

english, 2006

17

Plasma copper/zinc ratio: an inflammatory/nutritional biomarker as predictor of all-cause mortality in elderly population

Marco Malavolta, Robertina Giacconi, Francesco Piacenza, Lory Santarelli, Catia Cipriano, Laura Costarelli, Silvia Tesei, Sara Pierpaoli, Andrea Basso, Roberta Galeazzi, Fabrizia Lattanzio, Eugenio Mo

Journal:

Year:

2010

Language:

english

File:

PDF, 280 KB

english, 2010

18

Association of MT1A haplotype with cardiovascular disease and antioxidant enzyme defense in elderly Greek population: comparison with an Italian cohort

Robertina Giacconi, Stavroula Kanoni, Patrizia Mecocci, Marco Malavolta, Dimitris Richter, Sara Pierpaoli, Laura Costarelli, Catia Cipriano, Elisa Muti, Francesca Mangialasche, Francesco Piacenza, Sil

Journal:

The Journal of Nutritional Biochemistry

Year:

2010

Language:

english

File:

PDF, 334 KB

english, 2010

19

Frequency of Polymorphisms of Signal Peptide of TGF-β1 and −1082G/A SNP at the Promoter Region of Il-10 Gene in Patients with Carotid Stenosis

ANTONIO CRIVELLO, ANTONIO GIACALONE, LETIZIA SCOLA, GIUSI IRMA FORTE, DOMENICO NUZZO, ROBERTINA GIACCONI, CATIA CIPRIANO, GIUSEPPINA CANDORE, EUGENIO MOCCHEGIANI, GIUSEPPINA COLONNA ROMANO, DOMENICO L

Journal:

Annals of the New York Academy of Sciences

Year:

2006

Language:

english

File:

PDF, 57 KB

english, 2006

20

Zinc, Metallothioneins, and Longevity: : Effect of Zinc Supplementation: Zincage Study

EUGENIO MOCCHEGIANI, ROBERTINA GIACCONI, CATIA CIPRIANO, LAURA COSTARELLI, ELISA MUTI, SILVIA TESEI, CINZIA GIULI, ROBERTA PAPA, FIORELLA MARCELLINI, ERMINIA MARIANI, LOTHAR RINK, GEORGE HERBEIN, AUDR

Journal:

Annals of the New York Academy of Sciences

Year:

2007

Language:

english

File:

PDF, 188 KB

english, 2007

21

The −174G/C polymorphism of IL-6 is useful to screen old subjects at risk for atherosclerosis or to reach successful ageing

Robertina Giacconi, Catia Cipriano, Francesco Albanese, Gianfranco Boccoli, Vittorio Saba, Fabiola Olivieri, Claudio Franceschi, Eugenio Mocchegiani

Journal:

Experimental Gerontology

Year:

2004

Language:

english

File:

PDF, 134 KB

english, 2004

22

The variations during the circadian cycle of liver CD1d-unrestricted NK1.1+TCRγ/δ+ cells lead to successful ageing. Role of metallothionein/IL-6/gp130/PARP-1 interplay in very old mice

Eugenio Mocchegiani, Robertina Giacconi, Catia Cipriano, Nazzarena Gasparini, Gianni Bernardini, Marco Malavolta, Marta Menegazzi, Elisabetta Cavalieri, Mario Muzzioli, Anna Rosa Ciampa, Hisanori Suzu

Journal:

Experimental Gerontology

Year:

2004

Language:

english

File:

PDF, 427 KB

english, 2004

23

Zinc-binding proteins (metallothionein and α-2 macroglobulin) and immunosenescence

Eugenio Mocchegiani, Laura Costarelli, Robertina Giacconi, Catia Cipriano, Elisa Muti, Marco Malavolta

Journal:

Experimental Gerontology

Year:

2006

Language:

english

File:

PDF, 298 KB

english, 2006

24

Zinc deficiency and IL-6 −174G/C polymorphism in old people from different European countries: Effect of zinc supplementation. ZINCAGE study

Eugenio Mocchegiani, Robertina Giacconi, Laura Costarelli, Elisa Muti, Catia Cipriano, Silvia Tesei, Sara Pierpaoli, Cinzia Giuli, Roberta Papa, Fiorella Marcellini, Nazzarena Gasparini, Romeo Pierand

Journal:

Experimental Gerontology

Year:

2008

Language:

english

File:

PDF, 213 KB

english, 2008

25

1267 HSP70-2 polymorphism as a risk factor for carotid plaque rupture and cerebral ischaemia in old type 2 diabetes-atherosclerotic patients

Robertina Giacconi, Calogero Caruso, Domenico Lio, Elisa Muti, Catia Cipriano, Vittorio Saba, Gianfranco Boccoli, Nazzarena Gasparini, Marco Malavolta, Eugenio Mocchegiani

Journal:

Mechanisms of Ageing and Development

Year:

2005

Language:

english

File:

PDF, 152 KB

english, 2005

26

A genetic variant near the equine interleukin 6 gene associated with copper:zinc ratio

Daniela Beghelli, Robertina Giacconi, Eugenio Mocchegiani, Catia Cipriano, Marco Malavolta, Carlo Renieri

Journal:

The Veterinary Journal

Year:

2011

Language:

english

File:

PDF, 318 KB

english, 2011

27

Erratum to “Zinc, infections and immunosenescence”: [Mech. Ageing Develop. 121(2000) 21–35]

Eugenio Mocchegiani, Robertina Giacconi, Mario Muzzioli, Catia Cipriano

Journal:

Mechanisms of Ageing and Development

Year:

2001

Language:

english

File:

PDF, 34 KB

english, 2001

28

Metallothioneins (I+II) and thyroid–thymus axis efficiency in old mice: role of corticosterone and zinc supply

Eugenio Mocchegiani, Robertina Giacconi, Catia Cipriano, Nazzarena Gasparini, Fiorenza Orlando, Rosalia Stecconi, Mario Muzzioli, Gloria Isani, Emilio Carpenè

Journal:

Mechanisms of Ageing and Development

Year:

2002

Language:

english

File:

PDF, 569 KB

english, 2002

29

Interrelationships among brain, endocrine and immune response in ageing and successful ageing: role of metallothionein III isoform

Robertina Giacconi, Catia Cipriano, Mario Muzzioli, Nazzarena Gasparini, Florenza Orlando, Eugenio Mocchegiani

Journal:

Mechanisms of Ageing and Development

Year:

2003

Language:

english

File:

PDF, 279 KB

english, 2003

30

Metallothionein (I+II) confers, via c-myc, immune plasticity in oldest mice: model of partial hepatectomy/liver regeneration

Catia Cipriano, Robertina Giacconi, Mario Muzzioli, Nazzarena Gasparini, Fiorenza Orlando, Attilio Corradi, Enrico Cabassi, Eugenio Mocchegiani

Journal:

Mechanisms of Ageing and Development

Year:

2003

Language:

english

File:

PDF, 391 KB

english, 2003

31

Zinc, T-cell pathways, aging: role of metallothioneins

Eugenio Mocchegiani, Mario Muzzioli, Catia Cipriano, Robertina Giacconi

Journal:

Mechanisms of Ageing and Development

Year:

1998

Language:

english

File:

PDF, 129 KB

english, 1998

32

MtmRNA gene expression, via IL-6 and glucocorticoids, as potential genetic marker of immunosenescence: lessons from very old mice and humans

Eugenio Mocchegiani, Robertina Giacconi, Catia Cipriano, Mario Muzzioli, Nazzarena Gasparini, Raffaella Moresi, Rosalia Stecconi, Hisanori Suzuki, Elisabetta Cavalieri, Erminia Mariani

Journal:

Experimental Gerontology

Year:

2002

Language:

english

File:

PDF, 133 KB

english, 2002

33

Metallothionein isoforms (I + II and III) and interleukin-6 in the hippocampus of old rats: may their concomitant increments lead to neurodegeneration?

Eugenio Mocchegiani, Robertina Giacconi, Patrizia Fattoretti, Tiziana Casoli, Catia Cipriano, Elisa Muti, Marco Malavolta, Giuseppina DiStefano, Carlo Bertoni-Freddari

Journal:

Brain Research Bulletin

Year:

2004

Language:

english

File:

PDF, 387 KB

english, 2004

34

CD14 C (-260)T polymorphism, atherosclerosis, elderly: Role of cytokines and metallothioneins

Robertina Giacconi, Calogero Caruso, Domenico Lio, Elisa Muti, Catia Cipriano, Laura Costarelli, Vittorio Saba, Nazzarena Gasparini, Marco Malavolta, Eugenio Mocchegiani

Journal:

International Journal of Cardiology

Year:

2007

Language:

english

File:

PDF, 203 KB

english, 2007

35

Zinc-bound metallothioneins as potential biological markers of ageing

Eugenio Mocchegiani, Robertina Giacconi, Catia Cipriano, Mario Muzzioli, Patrizia Fattoretti, Carlo Bertoni-Freddari, Gloria Isani, Pamela Zambenedetti, Paolo Zatta

Journal:

Brain Research Bulletin

Year:

2001

Language:

english

File:

PDF, 297 KB

english, 2001

36

Metallothionein Downregulation in Very Old Age: A Phenomenon Associated with Cellular Senescence?

Malavolta, Marco, Cipriano, Catia, Costarelli, Laura, Giacconi, Robertina, Tesei, Silvia, Muti, Elisa, Piacenza, Francesco, Pierpaoli, Sara, Larbi, Annis, Pawelec, Graham, Dedoussis, George, Herbein,

Journal:

Rejuvenation Research

Year:

2008

Language:

english

File:

PDF, 162 KB

english, 2008

37

l-Arginine normalizes NOS activity and zinc-MT homeostasis in the kidney of mice chronically exposed to inorganic mercury

Francesco Piacenza, Marco Malavolta, Catia Cipriano, Laura Costarelli, Robertina Giacconi, Elisa Muti, Silvia Tesei, Sara Pierpaoli, Andrea Basso, Massimo Bracci, Viviana Bonacucina, Lory Santarelli,

Journal:

Toxicology Letters

Year:

2009

Language:

english

File:

PDF, 284 KB

english, 2009

38

Zinc Homeostasis in Aging: Two Elusive Faces of the Same "Metal"

Mocchegiani, Eugenio, Costarelli, Laura, Giacconi, Robertina, Cipriano, Catia, Muti, Elisa, Rink, Lothar, Malavolta, Marco

Journal:

Rejuvenation Research

Year:

2006

Language:

english

File:

PDF, 472 KB

english, 2006

39

Combining UHR-SEC-HPLC-ICP-MS with flow cytometry to quantify metallothioneins and to study zinc homeostasis in human PBMC

Malavolta, Marco, Piacenza, Francesco, Costarelli, Laura, Giacconi, Robertina, Muti, Elisa, Cipriano, Catia, Tesei, Silvia, Spezia, Sandro, Mocchegiani, Eugenio

Journal:

Journal of Analytical Atomic Spectrometry

Year:

2007

Language:

english

File:

PDF, 784 KB

english, 2007

40

Modulation of Genes Involved in Zinc Homeostasis in Old Low-Grade Atherosclerotic Patients Under Effects of HMG-CoA Reductase Inhibitors

Costarelli, Laura, Muti, Elisa, Malavolta, Marco, Giacconi, Robertina, Cipriano, Catia, Sartini, Davide, Emanuelli, Monica, Silvestrini, Mauro, Provinciali, Leandro, Gobbi, Beatrice, Mocchegiani, Euge

Journal:

Rejuvenation Research

Year:

2008

Language:

english

File:

PDF, 60 KB

english, 2008

41

A Novel Zip2 Gln/Arg/Leu Codon 2 Polymorphism Is Associated with Carotid Artery Disease in Aging

Giacconi, Robertina, Muti, Elisa, Malavolta, Marco, Cardelli, Maurizio, Pierpaoli, Sara, Cipriano, Catia, Costarelli, Laura, Tesei, Silvia, Saba, Vittorio, Mocchegiani, Eugenio

Journal:

Rejuvenation Research

Year:

2008

Language:

english

File:

PDF, 60 KB

english, 2008

42

Effects of β-caryophyllene and Murraya paniculata essential oil in the murine hepatoma cells and in the bacteria and fungi 24-h time–kill curve studies

Selestino Neta, Maria Cipriano, Vittorazzi, Catia, Guimarães, Aline Cristina, Martins, João Damasceno Lopes, Fronza, Marcio, Endringer, Denise Coutinho, Scherer, Rodrigo

Journal:

Pharmaceutical Biology

Year:

2017

Language:

english

File:

PDF, 1.12 MB

english, 2017